Sepsis Markers in Early Neonatal Diagnosis

Early and accurate identification of sepsis in neonates is critical for reducing morbidity and mortality. This session focuses on the clinical utility of emerging sepsis markers, such as C-reactive protein (CRP), procalcitonin (PCT), interleukins, and blood cultures, in guiding early diagnosis and therapeutic decisions. As clinical signs of sepsis are often nonspecific, combining biomarker data with vital sign trends and risk factor assessments enhances diagnostic confidence. Participants will explore the role of serial measurements, point-of-care testing, and the integration of lab findings with electronic health records to identify at-risk neonates quickly. The potential of novel biomarkers and sepsis prediction algorithms using AI will also be discussed. By improving diagnostic accuracy, these tools can help reduce unnecessary antibiotic use, lower resistance risks, and support antimicrobial stewardship efforts. Understanding which markers are most appropriate for early versus late-onset sepsis and how to interpret results in different clinical contexts can greatly influence patient outcomes and treatment efficiency.

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